SAR7334 hydrochloride ( —— )

产品货号. M33118 CAS No. 1333207-63-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SAR7334 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SAR7334 hydrochloride 是一种有效的 TRPC6 特异性抑制剂，能够抑制 TRPC6 电流，IC50 值为 7.9 nM。
产品描述

SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
体外实验

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226?nM, whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9?nM. SAR7334 (100?nM) substantially reduces TRPC6 currents.
体内实验

SAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
同义词

——
通路

Others
靶点

Other Targets
受体

Others
研究领域

——
适应症

——

CAS Number

1333207-63-8
分子量

440.79
分子式

C21H24Cl3N3O
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (226.87 mM; 超声助溶 ) H2O 中的溶解度 : 50 mg/mL (113.43 mM; 超声助溶)
SMILES

Cl.Cl.N[C@@H]1CCCN(C1)[C@@H]1Cc2ccccc2[C@H]1Oc1ccc(cc1Cl)C#N
化学全称

——

1. Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299.?

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